Research Associate/Sr. Research Associate in vivo pharmacology
Company: Signify Bio
Location: Dallas
Posted on: January 10, 2026
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Job Description:
Job Description Company Description Signify Bio is a pioneering
early-stage RNA/LNP biotechnology company harnessing the human body
for the production of in situ protein therapeutics. We aim to
create personalized medicines for all by combining the promise of
signal peptide engineered control with the speed and power of mRNA
encoded design. With labs in Dallas, TX, we are building three
proprietary and novel platforms encompassing both nucleic acid
payloads and non-viral delivery systems designed to control the
production, secretion and localization of protein therapeutics
directly within the human body. Role Description We are adding a
Research Associate/Senior Research Associate (non-PhD) to our
Translational Sciences team to execute in vivo pharmacology and
molecular biology studies. Primary responsibility will be
conducting in vivo studies to identify and progress lead
formulations towards the clinic. This role involves handling and
dosing rodents, collecting samples for downstream biochemical
assessments, execution of biochemical assessments, and maintaining
accurate records to support PK/PD, efficacy, and safety in vivo and
molecular biology studies. Essential Duties and Responsibilities ?
Design and perform in vivo pharmacology studies in rodent models,
including dosing (IV, IP, SC, IM) and tissue collection in mice and
rats ? Collect and process biological samples (blood, liver,
muscle, and other organs) for downstream analysis ? Design, perform
and analyze molecular biology experiments, including ELISA, WB,
QPCR ? Maintain accurate records of experiments, protocols, and
data in electronic lab notebooks (ELN). ? Collaborate daily with
cross-functional teams, including Biology and Formulations ? Ensure
compliance with IACUC protocols and maintain high standards of
animal welfare Qualifications ? BS/MS in Life Sciences, including
Pharmacology, Immunology, Biology, or a related field with 2-5
years of in vivo research experience (industry experience
preferred) ? Hands-on experience with rodent (rat and mouse)
handling, dosing techniques, in-life and terminal blood collection,
and necropsy. ? Proficiency with i.v, s.c, and i.m. injections and
blood collection by various methods ? Proficiency with molecular
biology techniques and methods, including ELISA, WB, QPCR ?
Proficient in Word, Excel, PowerPoint, and GraphPad Prism. ? Highly
adaptable and capable of adjusting to shifting priorities. ? Able
to work in a fast-paced and highly collaborative environment. ?
Excellent organizational and communication skills. ? Strong
attention to detail. Physical Requirements This lab-based position
requires the ability to stand for extended periods as well as
occasional need to reach, bend, stoop, and climb stairs. Working
with rodent cages may require working in an uncomfortable physical
position briefly in order to change or clean cages. Lifting
requirement may occasionally be up to approximately 25 lbs.
Pushing/pulling carts or cage racks may be required. Manual
dexterity and fine motor skills are needed to handle small animals.
Position involves regular exposure to biological materials such as
animal allergens and requires regular use of Personal Protective
Equipment (gown, mask, gloves) and strict compliance with
Environmental Health & Safety guidelines. Sorry, no relocation
assistance or immigration sponsorship is available for this
position. Signify Bio is committed to equal employment opportunity
and non-discrimination for all employees and qualified applicants
without regard to a person's race, color, sex, gender identity or
expression, age, religion, national origin, ancestry, ethnicity,
disability, veteran status, genetic information, sexual
orientation, marital status, or any characteristic protected under
applicable law.
Keywords: Signify Bio, Mesquite , Research Associate/Sr. Research Associate in vivo pharmacology, Science, Research & Development , Dallas, Texas
